Target DNA induced switches of DNA polymerase activity.
نویسندگان
چکیده
A novel concept that target DNA can induce switching of DNA polymerase activity is devised. The method relies on the finding that a DNA aptamer can undergo conformational change upon hybridization with a complementary target DNA, which leads to activation or inactivation of DNA polymerase. This strategy is utilized to identify the presence of target DNA with high levels of sensitivity and selectivity.
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عنوان ژورنال:
- Chemical communications
دوره 51 49 شماره
صفحات -
تاریخ انتشار 2015